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Fertile eunuch syndrome
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Fertile eunuch syndrome : ウィキペディア英語版
Fertile eunuch syndrome
The fertile eunuch syndrome is a cause of hypogonadotropic hypogonadism caused by a lutheinizing hormone deficiency.〔 Valdes-Socin H, Rubio Almanza M, Tomé Fernández-Ladreda M, Debray FG, Bours V, Beckers A. Reproduction, Smell and Neurodevelopmental disorders: Genetic defects in different hypogonadotropic hypogonadal syndromes. Frontiers in Endocrinology 2014;jul 9;5:109. doi: 10.3389/fendo.2014.00109. 〕 It is characterized by hypogonadism with spermatogenesis.〔 Valdes-Socin H Beckers A. Pasqualini’s syndrome: hypoandrogenism with spermatogenesis. MEDICINA (Buenos Aires) 2015; 75: 53-58. 〕
Pasqualini and Bur published the first case of eunuchoidism with preserved spermatogenesis in 1950 in la Revista de la Asociación Médica Argentina.〔Pasqualini RQ, Bur GE. Síndrome hipoandrogénico con gametogénesis conservada. Rev Asoc Méd Argent 1950; 64: 6.〕
The hypoandrogenism with spermatogenesis syndrome included: (a) eunuchoidism, (b) testis with normal spermatogenesis and full volume, with mature spermatozoids in a high proportion of seminiferous tubes and undifferentiated and immature Leydig cells (c) full functional compensation through the administration of chorionic gonadotropin hormone, while hCG is administered (d) total urinary gonadotrophins within normal limits (e) this definition implies the normal activity of the pituitary and the absence of congenital malformations in general. In describing five other similar cases in 1953, Mc Cullagh & al 〔 McCullagh EP, Beck JC, Schaffenburg CA: A syndrome of eunuchoidism with spermatogenesis, normal urinary FSH and low or normal ICSH: (“Fertile eunuchs”). J Clin Endocrinol Metab 1953; 13: 49.〕 〔

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